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Other uses for this medicineReturn to top cardura effects side What special precautions should I follow?Return to top cardura generic order you should know that doxazosin may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. This is more common when you first start taking doxazosin and when your dose is increased. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up. If you experience these symptoms, sit or lie down. cardura medication Your doctor may prescribe a low-salt or low-sodium diet. Follow these directions carefully. cardura effects medication side What side effects can this medication cause?Return to top cardura xl
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drowsiness cardura fainting cardura generic If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online [at http://www.fda.gov/MedWatch/report.htm] or by phone [1-800-332-1088]. cardura medicine Google is neither affiliated with the authors of this page nor responsible for its content. --------------------------------------------------------------------------------
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2CLINICAL PHARMACOLOGYPharmacodynamicsA. Benign Prostatic Hyperplasia (BPH)Benign prostatic hyperplasia (BPH) is a common cause of urinary outflow obstruction in agingmales. Severe BPH may lead to urinary retention and renal damage. A static and a dynamic component contribute to the symptoms and reduced urinary flow rate associated with BPH. The static component is related to an increase in prostate size caused, in part, by a proliferation of smooth muscle cells in the prostatic stroma. However, the severity of BPH symptoms and thedegree of urethral obstruction do not correlate well with the size of the prostate. The dynamiccomponent of BPH is associated with an increase in smooth muscle tone in the prostate and bladder neck. The degree of tone in this area is mediated by the alpha1adrenoceptor, which is present in high density in the prostatic stroma, prostatic capsule and bladder neck. Blockade of the alpha1receptor decreases urethral resistance and may relieve the obstruction and BPH symptoms. In the human prostate, CARDURAÆ antagonizes phenylephrine (alpha1agonist)-induced contractions, in vitro, and binds with high affinity to the alpha1cadrenoceptor. The receptor subtype is thought to be the predominant functional type in the prostate. CARDURAÆacts within 1-2 weeks to decrease the severity of BPH symptoms and improve urinary flow rate. Since alpha1adrenoceptors are of low density in the urinary bladder (apart from the bladder neck), CARDURAÆ should maintain bladder contractility. The efficacy of CARDURAÆ was evaluated extensively in over 900 patients with BPH in double-blind, placebo-controlled trials. CARDURAÆ treatment was superior to placebo in improving patient symptoms and urinary flow rate. Significant relief with CARDURAÆ was seen as early as one week into the treatment regimen, with CARDURAÆ treated patients (N=173) showing a significant (p<0.01) increase in maximum flow rate of 0.8 mL/sec compared to a decrease of 0.5 mL/sec in the placebo group (N=41). In long-term studies improvement was maintained for up to 2 years of treatment. In 66-71% of patients, improvements above baseline were seen in both symptoms and maximum urinary flow rate. In three placebo-controlled studies of 14-16 weeks duration obstructive symptoms (hesitation, intermittency, dribbling, weak urinary stream, incomplete emptying of the bladder) and irritativesymptoms (nocturia, daytime frequency, urgency, burning) of BPH were evaluated at each visitby patient-assessed symptom questionnaires. The bothersomeness of symptoms was measured with a modified Boyarsky questionnaire. Symptom severity/frequency was assessed using a modified Boyarsky questionnaire or an AUA-based questionnaire. Uroflowmetric evaluations were performed at times of peak (2-6 hours post-dose) and/or trough (24 hours post-dose) plasma concentrations of CARDURAÆ. The results from the three placebo-controlled studies (N=609) showing significant efficacy with 4 mg and 8 mg doxazosin are summarized in Table 1. In all three studies, CARDURAÆ resulted in statistically significant relief of obstructive and irritative symptoms compared to placebo. Statistically significant improvements of 2.3-3.3 mL/sec in maximum flow rate were seen with CARDURAÆ in Studies 1 and 2, compared to 0.1-0.7 mL/sec with placebo. Page 9 Page 15 -------------------------------------------------------------------------------- 19Printed in U.S.A. 70-4538-00-9 Revised April 2002
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ï Avoid drinking alcohol, which can increase some of the side effects of Cardura. What are the possible side effects of Cardura? ∑ weakness; ï Your pharmacist has additional information about Cardura written for health professionals that you may read. This medication can be taken with or without food.
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--If you miss a dose... cardura generic order cardura effects medication side Store at room temperature. cardura What side effects may occur? More common side effects may include: cardura medication --------------------------------------------------------------------------------
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